Weed Firm 2: Back to College invites players on an exciting entrepreneurial journey in the cannabis industry. This sequel to the popular Weed Firm: RePlanted expands upon the original's farming simulation, introducing new challenges and opportunities. Players cultivate a diverse range of cannabis strains, including White Widow, Purple Haze, and Alien Weed, and expand their business to include hash, bubble hash, edibles, and concentrates.

The game features a unique underground location, the Hashienda Vault, where players refine their hash-making skills and meet a colorful cast of characters. Players must strategically manage their resources, cultivate high-quality products, and satisfy a demanding clientele, including the celebrity customer Soulja Boy. The game also incorporates elements of shop customization, security management, and evasion of law enforcement.

Beyond the core gameplay, players can explore interstellar trade at the Space Bar, selling concentrates to alien visitors. The storyline follows expelled botany student Ted Growing as he establishes his cannabis operation in an abandoned gym. Players must make careful decisions to balance growth, profit, and avoiding legal repercussions. The Hashienda Vault provides a significant expansion to the gameplay, adding depth and complexity to the process of cultivating and selling cannabis products.

The game encourages strategic planning, resource management, and client satisfaction to achieve dominance in the competitive cannabis market. The addition of new products and the interstellar trading element adds significant replayability. Ultimately, the goal is to build a thriving, profitable cannabis empire.